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Vidyalakshmi, Irengbam
- Evaluation of the Pattern and Mechanism of Bony Invasion in Gingivobuccal Sulcus and Gingival Squamous Cell Carcinoma and its Correlation with the Regional Lymph Node Metastasis:A Histopathological Study
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Study design: A prospective study in which 25 resected specimens of the jaws along with the associated lymph nodes of patients treated for GBS and gingival squamous cell carcinomas were evaluated for the frequency, pattern and mechanism of tumor invasion into the bone and the regional lymph node metastasis, using a light microscope.
Results: 8 of the 25 cases showed bony invasion, among which 5 (20%) showed invasive pattern of tumor invasion while 3 (12%) showed the erosive pattern into the bone. The main mechanism of bony invasion was via the cortical plate (20%) than the periodontal ligament (12%). Regional lymph node metastasis was seen in 6 of the 8 cases showing bony invasion. No significant correlation was found between any of the above parameters.
Conclusion: In our attempt to study the tumor invasion into the bone, we found no significant correlation between the pattern and mechanism of invasion and the regional lymph node metastasis. A possible treatment guide through our study to the surgeon from our side is to prevent aggressive resections and to preserve the integrity of the jaw and thus, to provide the maximum probability of cure and maintain the quality of life.
Authors
Irengbam Vidyalakshmi
1,
Abhilash Pasare
1,
T. V. Narayan
1,
Chaitanya N. Babu
1,
Shobith Shetty
1,
B. V. Prakruthi
1
Affiliations
1 Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, IN
1 Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, IN
Source
Journal of Pierre Fauchard Academy (India Section), Vol 31, No 2 (2017), Pagination: 93-98Abstract
Objective: The purpose of this study was to assess the frequency of bony invasion and to evaluate the pattern and mechanism of tumor invasion into the bone and its correlation with the regional lymph node metastasis in gingivobuccal sulcus (GBS) and gingival squamous cell carcinoma.Study design: A prospective study in which 25 resected specimens of the jaws along with the associated lymph nodes of patients treated for GBS and gingival squamous cell carcinomas were evaluated for the frequency, pattern and mechanism of tumor invasion into the bone and the regional lymph node metastasis, using a light microscope.
Results: 8 of the 25 cases showed bony invasion, among which 5 (20%) showed invasive pattern of tumor invasion while 3 (12%) showed the erosive pattern into the bone. The main mechanism of bony invasion was via the cortical plate (20%) than the periodontal ligament (12%). Regional lymph node metastasis was seen in 6 of the 8 cases showing bony invasion. No significant correlation was found between any of the above parameters.
Conclusion: In our attempt to study the tumor invasion into the bone, we found no significant correlation between the pattern and mechanism of invasion and the regional lymph node metastasis. A possible treatment guide through our study to the surgeon from our side is to prevent aggressive resections and to preserve the integrity of the jaw and thus, to provide the maximum probability of cure and maintain the quality of life.
Keywords
Gingivobuccal Complex, Erosive Pattern, Invasive Pattern.References
- Shah JS, Johnson NW, Batsakis JG. Oral Cancer. 1st ed. United Kingdom: Martin Dunitz; 2003.
- Hadler-Oslen E, Wetting HL, Rikardsen O, et al. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Arch. 2010;457:677–692.
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- Walvekar RR, Chaukar DA, Deshpande MS, et al. Squamous cell carcinoma of the gingivobuccal complex: predictors of locoregional failure in stage III–IV cancers. Oral Oncol. 2009;45:135–140.
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- An Institutional Study for Determining the Correlation of Oral Submucous Fibrosis with Serum Haemoglobin Level:A Retrospective Analysis of 100 Cases
Abstract Views :236 |
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Materials and methods: In this institutional study, 100 clinically diagnosed and histopathologically confirmed OSF patients were retrieved, of which 68 patients were included in the study along with 30 healthy controls. Serum haemoglobin levels were retrieved retrospectively from the haematological records.
Results: The study showed no significant correlation between OSF and serum haemoglobin. Serum haemoglobin in the study group and the control group did not show any significant difference.
Conclusion: There is no significant correlation between the serum haemoglobin level with OSF and also with control groups. Further large-scale prospective studies with different stages of OSF are indicated to find a correlation between the level of serum haemoglobin and OSF in this part of the country.
Authors
Affiliations
1 Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, IN
1 Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, IN
Source
Journal of Pierre Fauchard Academy (India Section), Vol 31, No 1 (2017), Pagination: 14-17Abstract
Aim: Oral submucous fibrosis (OSF) is a potentially malignant, chronic progressive disorder affecting most parts of the oral cavity with different clinical presentation depending upon the stage of the disease. It has multifactorial aetiology triggering the disease process. Aetiological factors that have been attributed are areca nut chewing, nutritional deficiencies, immunological processes and genetic predisposition. Patients with OSF show significant decrease in the level of haemoglobin causing anaemia. The aim of this study was to find for any correlation between the serum haemoglobin level and OSF.Materials and methods: In this institutional study, 100 clinically diagnosed and histopathologically confirmed OSF patients were retrieved, of which 68 patients were included in the study along with 30 healthy controls. Serum haemoglobin levels were retrieved retrospectively from the haematological records.
Results: The study showed no significant correlation between OSF and serum haemoglobin. Serum haemoglobin in the study group and the control group did not show any significant difference.
Conclusion: There is no significant correlation between the serum haemoglobin level with OSF and also with control groups. Further large-scale prospective studies with different stages of OSF are indicated to find a correlation between the level of serum haemoglobin and OSF in this part of the country.
Keywords
Oral Submucous Fibrosis, Serum Haemoglobin, Iron Deficiency Anaemia.References
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- Clark SF. Iron deficiency anemia: diagnosis and management. Curr Opin Gastroenterol. 2009;25:122–128.
- Rajendran R, Sivapathasundharam B. Shafer's Textbook of Oral Pathology. 6th ed. Elsevier India; 2009:86–100.
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